Hebrew University of Jerusale

Prof. Amiram Goldblum's

School of Pharmacy
Molecular Modeling and Drug Design Group

Tal Tabakman

MSc student

Computational design of protein-protein interactions

Project Description
Design of protein-protein interaction has implications for both understanding of biological systems and for drug developments. In my research I try to optimize binding interactions in binary protein complexes by computationally redesign residues at interface positions. My focus is on the optimization of binding of coiled coils proteins and specifically, the BCR protein that when forming a homodimer is responsible for the CML (chronic myeloid leukemia) disease. The protein redesign process is built on our method for optimization for highly complex system – the ISE algorithm.

2005 - now M.Sc, School of Pharmacy, The Hebrew University of Jerusalem
2002 - 2005 BSc at computer science and computational biology, Hebrew University, Jerusalem.

email tabakt@pob.huji.ac.il
Room 424


Last Update : September 9, 2006 | Copyright ©, 2006, The Hebrew University of Jerusalem. All Rights Reserved.