Hebrew University of Jerusale

Prof. Amiram Goldblum's


School of Pharmacy
Molecular Modeling and Drug Design Group



David Marcus


PhD student


Implementations of the ISE Algorithm in Cheminformatics

Project Description
In my project I try to use the ISE algorithm with complexed combinatorial problems in cheminformatics, such as:
  • Distinguishing between active and inactive (or less active) molecules (on a specific target)
  • Drug likeness
  • Selectivity
  • QSAR/QSPR (solubility, BBB passage etc.)

Other Projects
  • Managing the group servers and websites

Education
2005 - now PhD Student, School of Pharmacy, The Hebrew University of Jerusalem
2002 - 2005 M.Sc, School of Pharmacy, The Hebrew University of Jerusalem
Thesis subject: "Using Multiple Binding Modes in Structure Based Drug Design to the Estrogen Receptor" guided by Prof. Amiram Goldblum
1998 - 2002 B.Pharm, School of Pharmacy, The Hebrew University of Jerusalem

Publications
• Marcus D. and Goldblum A., MulBind: Scoring Multiple Binding Modes of Diverse Scaffolds, Proceedings of the 15th European Synposium on QSAR and Molecular Modeling, 2004; 491-492

• Marcus D. and Goldblum A., Pocket Creator: Carving Protein Binding Pockets from Ligands, 2006; Submitted to Bioinformatics

Contact
email mdavid@pob.huji.ac.il
Phone +972-2-6757116
Room 404

 

Last Update : September 9, 2006 | Copyright ©, 2006, The Hebrew University of Jerusalem. All Rights Reserved.